GEO series
LncRNA LUCAT1 and exosomal MIF induced by Helicobacter pylori promotes M2 macrophage polarization in gastric cancer
GSE288489
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/04/01
GPL24676
Summary
H. pylori infection induces upregulation of the long non-coding RNA LUCAT1 in gastric cancer cells, which facilitates the exosomal transfer of MIF (macrophage migration inhibitory factor) to the tumor microenvironment. This process shifts macrophages from the M0 to M2 phenotype, contributing to an aggressive gastric cancer progression by enhancing cell proliferation, migration, and invasion. The research suggests potential preventive and therapeutic strategies for gastric cancer by targeting LUCAT1 and MIF, highlighting the critical role of lncRNA-mediated mechanisms in H. pylori driven-cancer development.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE328275 Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer 28 samples
- GSE341753 Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis [RNA-Seq] 12 samples
- GSE319969 Spatial and Bulk Transcriptomic Profiling Defines the Molecular Evolution of Cutaneous Squamous Cell Carcinoma and Reveals Stage-Specific Biomarkers of Clinical Relevance [RNA-Seq] 24 samples
- GSE313035 METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin 67 samples
- GSE339456 Integrated bulk and spatial transcriptomic analysis identifies progression-associated molecular signatures in biopsy-proven hypertensive nephropathy [RNA-seq] 35 samples
- GSE342462 Integrated transcriptomic and bioelectrical profiling of stem-like cellular states in a colorectal cancer using SdFFF and UHF-DEP 12 samples
- GSE330029 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis [BulkRNAseq] 108 samples
- GSE341139 A conserved HAND2-BMP5-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 10 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.