GEO series
Role of progesterone receptor in inguinal hernia formation via skeletal muscle fibrosis [Hernia_Multiomics]
GSE288662
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
20 samples
2025/06/03
GPL24247
Summary
Inguinal hernia development has been linked to fibrosis and atrophy of the lower abdominal muscle (LAM). We have shown that exogenous adminstration of estradiol (E2) and progesterone (P4) in mice can induce LAM fibrosis, muscle atrophy, and hernia development in mice, and that concurrent inhibition of progesterone receptor signaling using the drug RU486 can prevent this process. Utilizing a combination of single-nuclear transcriptomics and epigenomics, we analyzed the effects of E2 and P4 on the different cell types in the LAM to determine how these compounds contribute to hernia development.
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Paper (PMID 40504614) ↗
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