Duplication of autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice [cortex]
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × RNA-seq Adult cortex CHD8 WT vs 5 × RNA-seq Adult cortex CHD8 KIGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in miceNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288732_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1219163 and SRA study SRP561517. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8774065 RNA-seq Adult cortex CHD8 WT rep1 RNA-seq Adult cortex CH…
- GSM8774066 RNA-seq Adult cortex CHD8 WT rep2 RNA-seq Adult cortex CH…
- GSM8774067 RNA-seq Adult cortex CHD8 WT rep3 RNA-seq Adult cortex CH…
- GSM8774068 RNA-seq Adult cortex CHD8 WT rep4 RNA-seq Adult cortex CH…
- GSM8774069 RNA-seq Adult cortex CHD8 WT rep5 RNA-seq Adult cortex CH…
- GSM8774070 RNA-seq Adult cortex CHD8 KI rep1 RNA-seq Adult cortex CH…
- GSM8774071 RNA-seq Adult cortex CHD8 KI rep2 RNA-seq Adult cortex CH…
- GSM8774072 RNA-seq Adult cortex CHD8 KI rep3 RNA-seq Adult cortex CH…
- GSM8774073 RNA-seq Adult cortex CHD8 KI rep4 RNA-seq Adult cortex CH…
- GSM8774074 RNA-seq Adult cortex CHD8 KI rep5 RNA-seq Adult cortex CH…
- GSE263334 Duplication of autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice 40 samples shares chd8, neurodevelopmental, autism-related, hyperactivity, duplication, behavioral, defects
- GSE283523 Title: Neurodevelopmental and behavioral defects in congenital heart disease 8 samples shares neurodevelopmental, behavioral, defects
- GSE283526 Neurodevelopmental and behavioral defects in congenital heart disease [EMX-cre RNAseq] 6 samples shares neurodevelopmental, behavioral, defects
- GSE283524 Neurodevelopmental and behavioral defects in congenital heart disease [ChIP-seq] 2 samples shares neurodevelopmental, behavioral, defects
- GSE293602 Transcriptome analysis in the prefrontal cortex of Chd8+/N2373K heterozygous mice treated with drug 60 samples shares chd8, cortex
- GSE294125 Transcriptome analysis in the prefrontal cortex of Chd8-S62X heterozygous mice treated with drug 59 samples shares chd8, cortex
- GSE279810 Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8 18 samples shares chd8, autism-related
- GSE266671 Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency 2 samples shares neurodevelopmental, defects
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.