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Human papillomavirus (HPV) infected epithelial cells and FBLN1+ fibroreticular cells govern the immunogenic tumor microenvironment in HPV-associated oropharyngeal squamous cell carcinoma

GSE288786 Homo sapiens Expression profiling by high throughput sequencing 10 samples 2026/04/30 GPL18573
Summary
OPSCC can occur through either the exposure to carcinogens such as alcohol and/or tobacco or high-risk human papillomavirus (HPV) infection. We used single cell RNA sequencing (scRNA-seq) to analyze the tumor microenvironment (TME) of HPV-positive OPSCC exhibits distinctive features, with relevance to the interaction between cancer cells and adjacent stromal cells.
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