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The Novel Transcriptional Co-regulator, ZMIZ1, Modulates Hormone Responses that are Essential for Optimal Endometrial Health [ChIP-Seq]

GSE288877 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 1 samples Submitted 2025/09/22 Platform GPL24676
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 1 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
1 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial functionThe Journal of clinical investigation · 2025
Summary (written by the submitters)
The endometrial expression and activity of the transcriptional co-regulator, Zinc Finger MIZ-Type Containing 1 (Zmiz1), that is co-localized with a mouse uterine estrogen receptor α (ERα)-binding super-enhancer, has not yet been evaluated. In human endometrial biopsy samples ZMIZ1 transcript and protein is dynamically expressed during the menstrual cycle.
Read the full summary ↓
ZMIZ1 mutations are associated with some uterine tumors and ZMIZ1 RNA levels are increased in endometrium from individuals with endometriosis. Disrupting ZMIZ1 in cultured human endometrial stromal cells or in mouse uterus prevented hormone-dependent proliferation of epithelial and stromal cells as well as decidual differentiation of stroma cells, triggering sterility. Additionally, aging-dependent fibrosis was accelerated in Zmiz1-targeted mouse uterus. Notably, ZMIZ1 deletion impacted expression of stromal cell progesterone receptor (PGR), which is essential for decidual transformation. ZMIZ1 and ERα were co-localized in nuclei of mouse uterine cells, and E2F, CCNA2 and FOXM1 signaling were all decreased when ZMIZ1 was targeted, which likely underlies reduced cell cycle progression. Transcriptomic analyses revealed that loss of ZMIZ1 alters the amplitude of estrogen regulated gene responses, indicating ZMIZ1 fine-tunes endometrial cell signals needed for optimal functioning. Our findings demonstrate the importance of ZMIZ1 as an ERα co-regulator in uterine biology and pathology.
Published in
Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function
Hewitt SC, Orellana F, Marquardt RM et al. · The Journal of clinical investigation 2025 · PMID 41321316 · doi:10.1172/JCI193212
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288877_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1219666 and SRA study SRP561823. Searching any of these in the dataset finder brings you back here.

Samples in this study

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.