GEO series
Prostaglandin and prostacyclin regulation of Th1 responses [ptgir_ko]
GSE288921
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2025/06/12
GPL24247
Summary
Metabolic reprogramming is an integral component of normal Th1 induction and contraction. Whereas Th1 inducing signals are largely defined, the pathways underlying timely Th1 contraction remain poorly understood. Here, we show that a CD4+ T cell-intrinsic prostanoid lipid mediator production and signaling machinery, controlled by cell-autonomous complement C5, governs the Th1 shutdown program.
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Paper (PMID 40449486) ↗
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