T-bet regulates the maintenance and ASC differentiation potential of lymph node and lung effector memory B cell subsets
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsetsImmunity · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288942_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1220065 and SRA study SRP562091. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8779554 d1 replicated, bmem, tbx21neg, mdln+other, d30, gex
- GSM8779555 d1 replicated, bmem, tbx21neg, mdln+other, d30, vdj
- GSM8779556 d1 replicated, bmem, tbx21neg, mdln+other, d30, adt
- GSM8779557 d1 replicated, bmem, tbx21pos, mdln, d30, gex
- GSM8779558 d1 replicated, bmem, tbx21pos, mdln, d30, vdj
- GSM8779559 d1 replicated, bmem, tbx21pos, mdln, d30, adt
- GSM8779560 d2 replicated, bmem, tbx21neg, mdln+other, d30, gex
- GSM8779561 d2 replicated, bmem, tbx21neg, mdln+other, d30, vdj
- GSM8779562 d2 replicated, bmem, tbx21neg, mdln+other, d30, adt
- GSM8779563 d2 replicated, bmem, tbx21pos, mdln, d30, gex
- GSM8779564 d2 replicated, bmem, tbx21pos, mdln, d30, vdj
- GSM8779565 d2 replicated, bmem, tbx21pos, mdln, d30, adt
- GSE248272 Therapeutically targeting perivascular macrophage effector function improves CD8+ T-cell infiltration and response to chemotherapeutic drugs in cancer 30 samples shares asc, effector
- GSE261139 Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential 16 samples shares asc, potential
- GSE317032 Non-cytolytic viral vaccine vectors induce durable effector-memory CD8 T cell immunity by triggering type I interferon 18 samples shares effector, memory
- GSE255887 HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection 76 samples shares maintenance, effector
- GSE342312 T-bet and Runx3 orchestrate effector CD8 T cell differentiation and lineage fidelity through cooperative and distinct chromatin regulatory mechanisms [Multi-omics] 40 samples shares effector, t-bet
- GSE342096 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence 37 samples shares effector, memory
- GSE306744 Pre-division TCF1 downregulation determines long-term effector and memory CD8 T cell fates [RNA-Seq] 31 samples shares effector, memory
- GSE215759 Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells [RNA-seq] 15 samples shares effector, memory
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.