Blocking a Lipid Messenger from Osteocytes: A Novel Strategy for Prevention and Treatment of Metabolic Associated Fatty Liver Disease
RNA-seq (gene expression) · mouse · 9 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 9 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289033_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1220675 and SRA study SRP562231. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 9 sample titles: 9 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8782045 Vehicle 1 treatment under FFA conditions
- GSM8782046 Vehicle 2 treatment under FFA conditions
- GSM8782047 Vehicle 3 treatment under FFA conditions
- GSM8782048 Co-incubation of OCY-EV and antagomir-NC 1 followed by ultrafiltration, then hepatocytes under FFA conditions
- GSM8782049 Co-incubation of OCY-EV and antagomir-NC 2 followed by ultrafiltration, then hepatocytes under FFA conditions
- GSM8782050 Co-incubation of OCY-EV and antagomir-NC 3 followed by ultrafiltration, then hepatocytes under FFA conditions
- GSM8782051 Co-incubation of OCY-EV and antagomir-483-5p (1) followed by ultrafiltration, then hepatocytes under FFA conditions
- GSM8782052 Co-incubation of OCY-EV and antagomir-483-5p (2) followed by ultrafiltration, then hepatocytes under FFA conditions
- GSM8782053 Co-incubation of OCY-EV and antagomir483-5p (3) followed by ultrafiltration, then hepatocytes under FFA conditions
- GSE302447 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity 67 samples shares treatment, lipid
- GSE299691 Sex-dependent amelioration of laser-induced choroidal neovascularization by Short-Chain Fatty Acid treatment in a mouse model 43 samples shares treatment, fatty
- GSE307255 HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice 32 samples shares treatment, lipid
- GSE302442 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 3] 18 samples shares treatment, lipid
- GSE302441 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 2] 16 samples shares treatment, lipid
- GSE276648 Effect of blocking the IL-10 receptor on the microglial transcriptomic signature following chronic traumatic brain injury and nasal anti-CD3 treatment 12 samples shares treatment, blocking
- GSE272257 Treatment of neurologic disorders by brain-wide microglia replacement using a non-conditioning strategy 11 samples shares treatment, strategy
- GSE302440 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 1] 8 samples shares treatment, lipid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.