GEO series
RNA-sequencing of gastric tissues derived from five inflamed-type and five desert-type tumors
GSE289066
Mus musculus
Expression profiling by high throughput sequencing
10 samples
2025/02/18
GPL21103
Summary
Transforming gastric tumors from immunosuppressive to immunostimulatory is a potential approach to enhance immune checkpoint blockade response. Here, we developed a chromosomal instability subtype gastric cancer mouse model with an immunoactive tumor microenvironment (TME) and a stem cell-originated mouse-derived allograft model with an immunosuppressed TME to investigate mechanisms regulating the tumor immunophenotype and uncover therapeutic strategies to remodel the TME.
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