GEO series
TNF signature in advanced melanoma patients treated with immune checkpoint inhibitors: results from the MELANFα clinical study
GSE289084
Homo sapiens
Expression profiling by high throughput sequencing; Other
32 samples
2025/03/23
GPL24676GPL21697
Summary
Resistance to immune checkpoint inhibitors (ICI) in cancer patients is not fully understood and predictive biomarkers are lacking. MELANFα (NCT03348891) is an open-label, prospective, multicenter cohort of 60 patients with advanced melanoma receiving ICI (bitherapy: ipilimumab + nivolumab; monotherapy: pembrolizumab or nivolumab). In this study we collected blood from patients taken at baseline (week0) and 6 weeks after treatment initiation (week6), isolated peripheral blood monuclear cells and assessed the impact of treatment systemic immune responses to identify potential markers of response/resistance.
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Paper (PMID 40098565) ↗
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