GEO series
Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (ChIP-seq)
GSE289276
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/08/07
GPL18573GPL24676
Summary
Breast cancer is the most common cancer in women worldwide. SETD1A, a histone H3 lysine-4 methyltransferase, is associated with poor prognosis in breast cancer. While both its enzymatic and non-enzymatic functions have been implicated in cancer progression, the specific role of SETD1A in breast cancer remains unclear. This study aimed to elucidate the molecular mechanisms underlying SETD1A dependency in breast cancer.
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Paper (PMID 40790603) ↗
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