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RNA sequencing of dystrophin- and utrophin-deficient HeLa cells reveals overlapping transcriptomic alterations

GSE289357 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/27 Platform GPL24676
Summary
CRISPR/Cas9 and iRNA approaches were used to knock-out and knock-down expression of the dystrophin (DMD) and utrophin (UTRN) genes. RNA-sequencing analyses revealed overlapping transcriptomic alterations in HeLa cell lines relating to the observed phenotypic abnormalities, including increased membrane permeability and intracellular calcium levels, aggregation of mitochondria, elevated reactive oxygen species, increased cyto- and genotoxicity, and apoptosis.
Published in
Dystrophins DP71 and DP427 determine cell viability during proliferation and myofibre differentiation
Szwec S, Durska A, Kościelniak-Wawro P et al. · Cell death & disease 2026 · PMID 41965347 · doi:10.1038/s41419-026-08725-x
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Also filed as BioProject PRJNA1222773 and SRA study SRP563395. Searching any of these in the dataset finder brings you back here.

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