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Early Notch signaling programs effector CD8+ T cell differentiation [ATAC-Seq]

GSE289392 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/02/21 Platform GPL24247
Summary
A better understanding of the mechanisms regulating CD8+ T cell differentiation is essential to develop new strategies to fight infections and cancer. Using genetic mouse models and blocking antibodies, we uncovered cellular and molecular mechanisms by which Notch signaling favors efficient generation of effector CD8+ T cells. Using transcriptional and epigenetic studies, we identified a unique Notch-driven T cell-specific signature. Early Notch signals were associated with chromatin opening in regions occupied by bZIP transcription factors, specifically BATF, known to be important for CD8+ T cell differentiation. Overall, we show that the delivery of early Notch signals controls the molecular and functional fate of CD8+ T cells after infection.
Published in
Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation
Maurice De Sousa D, Perkey E, Le Corre L et al. · The Journal of experimental medicine 2025 · PMID 40111253 · doi:10.1084/jem.20231758
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Also filed as BioProject PRJNA1222843 and SRA study SRP563472. Searching any of these in the dataset finder brings you back here.

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