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Age-linked DNA Methylation and Gene Expression in Head and Neck Alveolar Rhabdomyosarcoma [RNA-seq]

GSE289529 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/08/13 Platform GPL18573
Summary
Alveolar rhabdomyosarcoma (ARMS) primarily affects children in the first decade of life, but it can also occur during adolescence, typically with a more favorable prognosis. This study aimed to explore DNA methylation (DNAm) and gene expression differences that could explain the poorer prognosis in younger patients. Whole-genome DNAm and transcriptome analyses were conducted on 10 head and neck ARMS samples, including 4 from patients under 1 year old and 6 from those over 10 years old. Although DNAm profiles were similar across age groups, significant differences in gene expression were identified. These findings suggest potential age-related molecular mechanisms and highlight candidate genes for further investigation as novel therapeutic targets. Notably, CDK9 emerged as a promising target, warranting further exploration in the context of ARMS treatment.
Published in
Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target
Patrizi S, Vallese S, Barresi S et al. · Pharmacological research 2025 · PMID 40350107 · doi:10.1016/j.phrs.2025.107767
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Also filed as BioProject PRJNA1223378. Searching any of these in the dataset finder brings you back here.

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