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Protective effect of mesaconate on autoimmune hepatitis via suppression of inflammatory response and oxidative stress

GSE289607 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/02 Platform GPL24247
Summary
Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease that currently lacks feasible drug treatment. Existing evidence suggests that mesaconate (MSA) exhibits immunomodulatory capacities, however, its role in AIH remains unclear. Here, we constructed a mouse model of AIH by administering concanavalin A (ConA) and conducted prophylactic administration to investigate the pharmacological effect of MSA on AIH and the underlying mechanisms of action. We found that pretreatment with MSA can effectively mitigate ConA-induced AIH by dampening the inflammatory response, oxidative stress, and apoptosis, both in vivo and in vitro. The underlying protective mechanism is associated with the inhibition of the IFN-γ-JAK1/2-STAT1 signaling pathway by MSA. Overall, our research not only validates the therapeutic potential of MSA for the management of AIH for the first time, but also provides a novel perspective and a promising therapeutic candidate for the future treatment of autoimmune disorders.
Published in
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress
Zhang Q, Wang J, He Y et al. · Journal of clinical and translational hepatology 2025 · PMID 41089709 · doi:10.14218/JCTH.2025.00112
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Also filed as BioProject PRJNA1223791 and SRA study SRP563953. Searching any of these in the dataset finder brings you back here.

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