STAT5 and STAT3 balance shapes dendritic cell function and tumor immunity
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 5 × BMDC, WT, LPS, vs 5 × BMDC, KO, LPS, vs 4 × BMDC, WT, Control, vs 4 × BMDC, KO, Control,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- STAT5 and STAT3 balance shapes dendritic cell function and tumour immunityNature · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289764_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1224740 and SRA study SRP564349. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 4 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8798138 BMDC, WT, LPS, rep1 BMDC, WT, LPS,
- GSM8798139 BMDC, WT, Control, rep1 BMDC, WT, Control,
- GSM8798140 BMDC, KO, LPS, rep1 BMDC, KO, LPS,
- GSM8798141 BMDC, KO, Control, rep1 BMDC, KO, Control,
- GSM8798142 BMDC, WT, LPS, rep2 BMDC, WT, LPS,
- GSM8798143 BMDC, KO, LPS, rep2 BMDC, KO, LPS,
- GSM8798144 BMDC, WT, LPS, rep3 BMDC, WT, LPS,
- GSM8798145 BMDC, WT, Control, rep2 BMDC, WT, Control,
- GSM8798146 BMDC, KO, LPS, rep3 BMDC, KO, LPS,
- GSM8798147 BMDC, KO, Control, rep2 BMDC, KO, Control,
- GSM8798148 BMDC, WT, LPS, rep4 BMDC, WT, LPS,
- GSM8798149 BMDC, WT, Control, rep3 BMDC, WT, Control,
- GSM8798150 BMDC, KO, LPS, rep4 BMDC, KO, LPS,
- GSM8798151 BMDC, KO, Control, rep3 BMDC, KO, Control,
- GSM8798152 BMDC, WT, LPS, rep5 BMDC, WT, LPS,
- GSM8798153 BMDC, WT, Control, rep4 BMDC, WT, Control,
- GSM8798154 BMDC, KO, LPS, rep5 BMDC, KO, LPS,
- GSM8798155 BMDC, KO, Control, rep4 BMDC, KO, Control,
- GSE293874 Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity [mouse bulk RNA-seq] 167 samples shares dendritic, immunity
- GSE245838 Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity [mouse scRNA-seq] 21 samples shares dendritic, immunity
- GSE295483 Type-I interferon priming signal balances anti-bacterial and anti-tumor trained immunity in alveolar macrophages [RNA-seq] 19 samples shares immunity, balance
- GSE300014 The CARM1 Epigenetic Enzyme Inhibits Cross-presenting Dendritic Cell Function in Cancer Immunity [RNA-seq] 26 samples shares dendritic, immunity
- GSE309228 Radiation induced YTHDF2 in dendritic cells impairs antitumor immunity 45 samples shares dendritic, immunity
- GSE235618 Effect of a dendritic cells derived extracellular vesicle as therapeutic vaccine platform to induce neuroprotective immunity for spinal cord injury 21 samples shares dendritic, immunity
- GSE283198 Combined Flt3L and CD40 agonism restores dendritic cell driven T cell immunity in mouse models and patients with pancreatic cancer [mouse] 13 samples shares dendritic, immunity
- GSE300019 The CARM1 Epigenetic Enzyme Inhibits Cross-presenting Dendritic Cell Function in Cancer Immunity [multiome] 8 samples shares dendritic, immunity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.