Analysis of the mechanism of acquisition of chemotherapy resistance in colorectal cancer cell lines
RNA-seq (gene expression) · human · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 27 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- GDF15 promotes 5-Fluorouracil and Oxaliplatin resistance by promoting stem cell-like phenotype in colorectal cancerBritish journal of cancer · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289766_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1224754 and SRA study SRP564354. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 9 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8798180 HCT116_WT_1 HCT116_WT
- GSM8798181 HCT116_WT_2 HCT116_WT
- GSM8798182 HCT116_WT_3 HCT116_WT
- GSM8798183 HCT116_5FU_1 HCT116_5FU
- GSM8798184 HCT116_5FU_2 HCT116_5FU
- GSM8798185 HCT116_5FU_3 HCT116_5FU
- GSM8798186 HCT116_OX_1 HCT116_OX
- GSM8798187 HCT116_OX_2 HCT116_OX
- GSM8798188 HCT116_OX_3 HCT116_OX
- GSM8798189 SW480_WT_1 SW480_WT
- GSM8798190 SW480_WT_2 SW480_WT
- GSM8798191 SW480_WT_3 SW480_WT
- GSM8798192 SW480_5FU_1 SW480_5FU
- GSM8798193 SW480_5FU_2 SW480_5FU
- GSM8798194 SW480_5FU_3 SW480_5FU
- GSM8798195 SW480_OX_1 SW480_OX
- GSM8798196 SW480_OX_2 SW480_OX
- GSM8798197 SW480_OX_3 SW480_OX
- GSM8798198 DLD1_WT_1 DLD1_WT
- GSM8798199 DLD1_WT_2 DLD1_WT
- GSM8798200 DLD1_WT_3 DLD1_WT
- GSM8798201 DLD1_5FU_1 DLD1_5FU
- GSM8798202 DLD1_5FU_2 DLD1_5FU
- GSM8798203 DLD1_5FU_3 DLD1_5FU
- GSM8798204 DLD1_OX_1 DLD1_OX
- GSM8798205 DLD1_OX_2 DLD1_OX
- GSM8798206 DLD1_OX_3 DLD1_OX
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE309004 Molecular determinants of neoadjuvant chemotherapy resistance in breast cancer: An analysis of gene expression and tumor microenvironment 54 samples shares chemotherapy, resistance
- GSE292601 Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1 62 samples shares chemotherapy, colorectal
- GSE200407 RNA-seq between between FOLFOX chemotherapy sensitivity and insensitivity in colorectal cancer 22 samples shares chemotherapy, colorectal
- GSE251958 Predicting patient outcome based on gene-expression biomarkers learned from colorectal cancer organoids and cell lines 21 samples shares colorectal, lines
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.