GEO series
Analysis of the mechanism of acquisition of chemotherapy resistance in colorectal cancer cell lines
GSE289766
Homo sapiens
Expression profiling by high throughput sequencing
27 samples
2026/04/09
GPL28038
Summary
Although anticancer drugs such as fluorouracil and oxaliplatin are widely used in the treatment of colorectal cancer, they are ineffective when cancer cells acquire drug resistance. The treatment strategy for colorectal cancer that has acquired drug resistance has become a problem in chemotherapy. To investigate the cause of drug resistance, we created drug-resistant strains of colon cancer cell lines by mixing a small amount of anticancer drug in the culture medium and culturing them for a long period of time, and explored the genetic changes by RNA-sequence.
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Paper (PMID 42120524) ↗
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