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Inhibition of microglial SLC2A5 attenuates brain injury following acute ischemic stroke [scRNA-Seq]

GSE289791 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/08 Platform GPL24247
Summary
The Slc2a5 in microglia plays a crucial role in the brain's injury response. In this study, we utilized single-cell RNA sequencing to examine the impact of Slc2a5 knockout on cell type-specific transcription in the brain. Additionally, we employed single-nucleus RNA sequencing to investigate the cell type-specific transcriptional changes in the brain 24 hours after transient middle cerebral artery occlusion (tMCAO) in response to ischemic stroke. Furthermore, RNA sequencing was conducted to analyze the effects of oxygen-glucose deprivation (OGD) conditions on the transcriptional profiles of wild-type and Slc2a5 knockout microglia in vitro.
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Also filed as BioProject PRJNA1224797 and SRA study SRP564420. Searching any of these in the dataset finder brings you back here.

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