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Transcriptome analysis of Enzalutamide-sensitive and -resistant CWR-R1, C4-2B, and VCaP cells

GSE290016 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/28 Platform GPL24676
Summary
Enzalutamide (ENZ) is an inhibitor of the androgen receptor (AR) widely used in managing castration-resistant prostate cancer (CRPC). However, ENZ is not curative due to the resistance CRPC inevitably develops. We hypothesize that there are commonly necessary elements of ENZ resistance in cells with different genetic mutations and treatment history. This study aims to identify differentially expressed genes in Enzalutamide-sensitive (ENZS) and ENZ-resistant (ENZR) C4-2B, CWR-R1, VCaP human prostate cell lines. We have identified 114 commonly upregulated genes in all three ENZR celll lines, which will be subjected to further investigation for their roles in ENZ resistance.
Published in
Aryl hydrocarbon receptor is critical for both AR-dependent and AR-indifferent enzalutamide resistance in castration-resistant prostate cancer
Chen CH, Brown R, Vander Griend DJ et al. · Oncogene 2026 · PMID 41872691 · doi:10.1038/s41388-026-03723-x
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Also filed as BioProject PRJNA1225742 and SRA study SRP565072. Searching any of these in the dataset finder brings you back here.

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