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Thymic alveolar type II epithelial mimetic cells revealed by Runx1-deficiency [CUT&Run]

GSE290143 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 3 samples Submitted 2026/04/23 Platform GPL19057
Summary
The mechanisms used to prevent autoimmune lung disease are incompletely understood. Recent studies in the thymus have identified unique populations of medullary thymic epithelial cells (mTECs) called mimetic cells that transcriptionally mimic peripheral epithelial populations. These mimetic cells have been found to have important functions in the thymus in immune tolerance and the diversity and cell types represented in this pool of cells represents an active area of investigation. Here, we utilized a mouse line with thymic specific deletion of the Runt related transcription factor 1 (Runx1) to identify a novel mimetic cell type that transcriptionally mimic alveolar type II (AT2) lung epithelial cells. Runx1 binds to genomic regions associated with epidermal growth factor receptor (EGFR) signaling suggesting a function for EGFR in regulating AT2 mTEC development.
Published in
Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency
Sin JH, Bowman CJ, Germino J et al. · Nature immunology 2026 · PMID 42185467 · doi:10.1038/s41590-026-02536-0
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Also filed as BioProject PRJNA1226264 and SRA study SRP565351. Searching any of these in the dataset finder brings you back here.

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