Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × KPC cell, shNC vs 3 × PANC02 cell, shNC vs 3 × PANC02 cell, shSrebf1 vs 2 × KPC cell, shSrebf1Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapyCancer communications (London, England) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290259_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1226923 and SRA study SRP565651. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8809397 KPC cell, shNC1 KPC cell, shNC
- GSM8809398 KPC cell, shNC2 KPC cell, shNC
- GSM8809399 KPC cell, shNC3 KPC cell, shNC
- GSM8809400 KPC cell, shSrebf1-1 KPC cell, shSrebf1
- GSM8809401 KPC cell, shSrebf1-2 KPC cell, shSrebf1
- GSM8809402 KPC cell, shSrebf3-3
- GSM8809403 PANC02 cell, shNC1 PANC02 cell, shNC
- GSM8809404 PANC02 cell, shNC2 PANC02 cell, shNC
- GSM8809405 PANC02 cell, shNC3 PANC02 cell, shNC
- GSM8809406 PANC02 cell, shSrebf1-1 PANC02 cell, shSrebf1
- GSM8809407 PANC02 cell, shSrebf1-2 PANC02 cell, shSrebf1
- GSM8809408 PANC02 cell, shSrebf1-3 PANC02 cell, shSrebf1
- GSE288530 Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis 18 samples shares sensitizes, pancreatic, lipid
- GSE320214 A Ketogenic Diet Sensitizes Pancreatic Cancer to Glutamine Metabolism Inhibitors 10 samples shares sensitizes, pancreatic
- GSE289275 Loss of ADAR1 in tumor cells activates cDC1s and sensitizes pancreatic cancer to immunotherapy 14 samples shares sensitizes, pancreatic
- GSE239364 MCRS1 sensitizes pancreatic cancer to T cell immunity [Tumor] 8 samples shares sensitizes, pancreatic
- GSE244012 Targeting Glycomes Sensitizes Ovarian Tumors to Immune Checkpoint Blockade 6 samples shares sensitizes, targeting
- GSE239358 MCRS1 sensitizes pancreatic cancer to T cell immunity [cellline RNA] 6 samples shares sensitizes, pancreatic
- GSE244367 Targeting Glycomes Sensitizes Ovarian Tumors to Immune Checkpoint Blockade II 4 samples shares sensitizes, targeting
- GSE239360 MCRS1 sensitizes pancreatic cancer to T cell immunity [scRNA] 3 samples shares sensitizes, pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.