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Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability

GSE290376 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/11/13 Platform GPL34328
Summary
We performed single cell RNA-sequencing (scRNAseq) identify which aortic cell types, differentially expressed genes, and biological pathways are affected by trimethylamine-N-oxide (TMAO). We also modeled cell-cell communications and intracellular gene regulatory networks to identify gene networks perturbed by TMAO feeding. The objective of this study was to characterize the cell type-dependent and independent effects of TMAO on key vascular cell types involved in atherosclerosis progression in vivo.
Published in
Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability
Cheng J, Cheng M, Sinha S et al. · Arteriosclerosis, thrombosis, and vascular biology 2025 · PMID 40808653 · doi:10.1161/ATVBAHA.125.323047
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Also filed as BioProject PRJNA1227590 and SRA study SRP566038. Searching any of these in the dataset finder brings you back here.

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