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LncRNA NEAT1 promotes immunosuppression in gastric cancer by maintaining the m6A methylation of SEMA3A in CAFs via exosomes under endoplasmic reticulum stress

GSE290384 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/15 Platform GPL24676
Summary
Endoplasmic reticulum stress (ERS) regulates the function of immune cells in the tumor microenvironment and suppresses the antitumor immune response. In order to formulate the TME of ERS-GC, we cocultured the human CAFs with the supernatant of human gastric cancer cells stimulated by TM. Mass spectrometry sequencing revealed that ERS state regulated the overexpression of 58 proteins and downregulation of the expression of 56 proteins in CAFs, including m6A-modified proteins and SEMA3A, an immunosuppression-related protein.
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LncRNA NEAT1 promotes immunosuppression in gastric cancer under endoplasmic reticulum stress by maintaining the M(6)A methylation of SEMA3A in CAFs
Xu Y, Xu R, Chen Z et al. · Molecular cancer 2026 · PMID 41782001 · doi:10.1186/s12943-026-02613-w
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Also filed as BioProject PRJNA1227851 and SRA study SRP566127. Searching any of these in the dataset finder brings you back here.

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