Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [RNA-seq]
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosiseLife · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290436_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1228024 and SRA study SRP566212. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 6 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8812720 E5 Control nanobody R1 E5 Control nanobody
- GSM8812721 E5 NES nanobody R1 E5 NES nanobody
- GSM8812722 E5 Control nanobody R2 E5 Control nanobody
- GSM8812723 E5 NES nanobody R2 E5 NES nanobody
- GSM8812724 E8 Control nanobody R1 E8 Control nanobody
- GSM8812725 E8 NES nanobody R1 E8 NES nanobody
- GSM8812726 E8 Control nanobody R2 E8 Control nanobody
- GSM8812727 E8 NES nanobody R2 E8 NES nanobody
- GSM8812728 AAVS1 control R1 AAVS1 control
- GSM8812729 AAVS1 NES R1 AAVS1 NES
- GSM8812730 AAVS1 control R2 AAVS1 control
- GSM8812731 AAVS1 NES R2 AAVS1 NES
- GSM8812732 AAVS1 control R3 AAVS1 control
- GSM8812733 AAVS1 NES R3 AAVS1 NES
- GSE290437 Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [miRNA-seq] 11 samples shares tdp43, mislocalization, amyotrophic, endogenous, inducible, sclerosis, lateral, rna-seq
- GSE283507 Ropinirole improves the amyotrophic lateral sclerosis phenotype of TDP43-mutant iPSC-derived motor neurons via a D2R-independent mechanism 54 samples shares tdp43, amyotrophic, sclerosis, lateral
- GSE314526 Differential Cellular Mechanisms Underlie Language and Executive Decline in Amyotrophic Lateral Sclerosis [RNA-seq] 72 samples shares amyotrophic, sclerosis, lateral, rna-seq
- GSE244263 Single-cell RNA-seq data of human PBMC from amyotrophic lateral sclerosis patients 40 samples shares amyotrophic, sclerosis, lateral, rna-seq
- GSE234297 RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery 144 samples shares amyotrophic, sclerosis, lateral
- GSE200474 Neurofilament accumulations in Amyotrophic Lateral Sclerosis patients’ motor neurons impair structural axonal initial segment integrity 65 samples shares amyotrophic, sclerosis, lateral
- GSE268995 Molecular Drivers of Neuroinflammation in Amyotrophic Lateral Sclerosis 40 samples shares amyotrophic, sclerosis, lateral
- GSE51684 Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences) 24 samples shares amyotrophic, sclerosis, lateral
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.