Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [miRNA-seq]
RNA-seq (gene expression) · human · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 11 samples: 3 × miRNA_AAVS1 control vs 3 × miRNA_AAVS1 NES vs 3 × miRNA_TDP43 shRNA vs 2 × miRNA_Control shRNAGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosiseLife · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290437_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1228027 and SRA study SRP566217. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8812734 miRNA_AAVS1 control R1 miRNA_AAVS1 control
- GSM8812735 miRNA_AAVS1 NES R1 miRNA_AAVS1 NES
- GSM8812736 miRNA_AAVS1 control R2 miRNA_AAVS1 control
- GSM8812737 miRNA_AAVS1 NES R2 miRNA_AAVS1 NES
- GSM8812738 miRNA_AAVS1 control R3 miRNA_AAVS1 control
- GSM8812739 miRNA_AAVS1 NES R3 miRNA_AAVS1 NES
- GSM8812740 miRNA_TDP43 shRNA R1 miRNA_TDP43 shRNA
- GSM8812741 miRNA_Control shRNA R1 miRNA_Control shRNA
- GSM8812742 miRNA_TDP43 shRNA R2 miRNA_TDP43 shRNA
- GSM8812743 miRNA_Control shRNA R2 miRNA_Control shRNA
- GSM8812744 miRNA_TDP43 shRNA R3 miRNA_TDP43 shRNA
- GSE290436 Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [RNA-seq] 14 samples shares tdp43, mislocalization, amyotrophic, endogenous, inducible, sclerosis, lateral
- GSE283507 Ropinirole improves the amyotrophic lateral sclerosis phenotype of TDP43-mutant iPSC-derived motor neurons via a D2R-independent mechanism 54 samples shares tdp43, amyotrophic, sclerosis, lateral
- GSE234297 RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery 144 samples shares amyotrophic, sclerosis, lateral
- GSE314526 Differential Cellular Mechanisms Underlie Language and Executive Decline in Amyotrophic Lateral Sclerosis [RNA-seq] 72 samples shares amyotrophic, sclerosis, lateral
- GSE200474 Neurofilament accumulations in Amyotrophic Lateral Sclerosis patients’ motor neurons impair structural axonal initial segment integrity 65 samples shares amyotrophic, sclerosis, lateral
- GSE244263 Single-cell RNA-seq data of human PBMC from amyotrophic lateral sclerosis patients 40 samples shares amyotrophic, sclerosis, lateral
- GSE268995 Molecular Drivers of Neuroinflammation in Amyotrophic Lateral Sclerosis 40 samples shares amyotrophic, sclerosis, lateral
- GSE51684 Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences) 24 samples shares amyotrophic, sclerosis, lateral
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.