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Transcriptional changes of adipocyte-deletion of Prmt5 in white adipocytes

GSE290506 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/01 Platform GPL15103
Summary
Adipose tissue (AT) is a crucial regulator of systemic energy homeostasis, and its dysfunction can lead to insulin resistance and other metabolic complications. Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetrical dimethylation of arginine residues to modulate protein stability and function. Here, we explore the function of PRMT5 in AT through RNA sequencing of wildtype and Prmt5 knockout (Prmt5AKO) mice. Our results demonstrate that Prmt5AKO alters the expression of genes related to metabolism and membrane transport. Specifically, Prmt5AKO induces genes enriched in glucose transport and glycolysis pathways, while suppressing genes encoding fatty acid (FA) transporters.
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Also filed as BioProject PRJNA1228524 and SRA study SRP566395. Searching any of these in the dataset finder brings you back here.

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