Transcriptomic analysis of sarcopenic obese mice reveals alterations in regulators of muscle force production, such as extracellular matrix remodeling and shifts in muscle fiber type
RNA-seq (gene expression) · mouse · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 19 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesityBMC genomics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290570_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1228639 and SRA study SRP566566. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 19 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8816775 [21] Young (6 months old); Lean (12% Kcal fat diet)
- GSM8816776 [22] Young (6 months old); Lean (12% Kcal fat diet)
- GSM8816777 [23] Young (6 months old); Lean (12% Kcal fat diet)
- GSM8816778 [24] Young (6 months old); Lean (12% Kcal fat diet)
- GSM8816779 [25] Young (6 months old); Obese (60% Kcal fat diet)
- GSM8816780 [26] Young (6 months old); Obese (60% Kcal fat diet)
- GSM8816781 [27] Young (6 months old); Obese (60% Kcal fat diet)
- GSM8816782 [28] Young (6 months old); Obese (60% Kcal fat diet)
- GSM8816783 [29] Young (6 months old); Obese (60% Kcal fat diet)
- GSM8816784 [30] Aged (20-21 months old); Lean (12% Kcal fat diet)
- GSM8816785 [31] Aged (20-21 months old); Lean (12% Kcal fat diet)
- GSM8816786 [32] Aged (20-21 months old); Lean (12% Kcal fat diet)
- GSM8816787 [33] Aged (20-21 months old); Lean (12% Kcal fat diet)
- GSM8816788 [34] Aged (20-21 months old); Lean (12% Kcal fat diet)
- GSM8816789 [35] Aged (20-21 months old); Obese (60% Kcal fat diet)
- GSM8816790 [36] Aged (20-21 months old); Obese (60% Kcal fat diet)
- GSM8816791 [37] Aged (20-21 months old); Obese (60% Kcal fat diet)
- GSM8816792 [38] Aged (20-21 months old); Obese (60% Kcal fat diet)
- GSM8816793 [39] Aged (20-21 months old); Obese (60% Kcal fat diet)
- GSE293383 Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity [RNA-seq] 12 samples shares extracellular, remodeling, matrix
- GSE284085 The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage. 12 samples shares extracellular, production, matrix
- GSE194082 Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (Bulk KO vs. WT SMC) 12 samples shares extracellular, production, matrix
- GSE295428 Spaceflight induces systemic effects on extracellular matrix and immune system in different age-stages 229 samples shares extracellular, matrix
- GSE289885 Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing 29 samples shares extracellular, matrix
- GSE269446 In vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion 23 samples shares extracellular, matrix
- GSE309618 Mesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture 18 samples shares extracellular, matrix
- GSE271194 Effect of genetic modification of extracellular matrix-related genes on B16F1 melanoma progression 15 samples shares extracellular, matrix
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.