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UHRF1-Mediated Maintenance DNA Methylation is Required for Induced Regulatory T Cell Function Following Influenza Induced Lung Injury in Young Adult Mice

GSE290605 Mus musculus (mouse) DNA methylation 140 samples Submitted 2025/09/03 Platform GPL30172
At a glance

DNA methylation · mouse · 140 samples

What it is
DNA methylationChemical marks on DNA that help switch genes on or off.
Organism
Mus musculus (mouse)
Samples
140 samples: 32 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
This dataset
Open GSE290605 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290605_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.

Also filed as BioProject PRJNA1228940 and SRA study SRP566555. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
32 conditions, mostly in triplicate
D24 lung Uhrf1+/+ iTreg ×9 D11 lung Uhrf1+/+ iTreg ×8 D11 lung UHRF1fl/fl iTreg ×8 D24 lung Uhrf1fl/fl iTreg ×7 D24 Uhrf1+/+ iTreg ×6 D24 Uhrf1fl/fl iTreg ×6 D11 Uhrf1+/+ iTreg ×6 D11 UHRF1fl/fl iTreg ×6 +24 more

Supports a between-group comparison across 140 samples.

How we read this: 32 replicated groups read from 140 sample titles; they account for 140 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 100 more — browse all 140 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.