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In-depth characterization of murine B-cell differentiation states: from pre-leukemia to leukemia [ATAC-seq]

GSE290658 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/03/04 Platform GPL24247
Summary
The overall goal of this study was to characterize bone marrow cells based on their transcriptome, epigenome, surface protein expression and BCR-VDJ-profile for accurate identification of clinically relevant cell states. This submission includes B-cell acute lymphoblastic (pre-)leukemia samples from mice. This project has received funding from ERA perMed JTC2018 under the title „Genomics-based tools for personalized treatment to reduce chemotherapy burden in paediatric cancer” (Acronym “GEPARD”)
Published in
Trajectories from single-cells to PAX5-driven leukemia reveal PAX5-MYC interplay in vivo
Auer F, Morcos MNF, Sipola M et al. · Leukemia 2025 · PMID 40394211 · doi:10.1038/s41375-025-02626-2
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Direct links to NCBI, no account and no request form: the whole study as GSE290658_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1229504 and SRA study SRP566906. Searching any of these in the dataset finder brings you back here.

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