GEO series
Keratinocyte-secreted SAA1 induces a population of long-lived antigen-presenting neutrophils that drives Sweet Syndrome
GSE291004
Homo sapiens
Expression profiling by high throughput sequencing
17 samples
2025/08/12
GPL28038
Summary
Sweet syndrome (also known as acute febrile neutrophilic dermatosis), is a rare inflammatory skin disorder characterized by erythematous plaques with a dense dermal neutrophilic infiltrate. It remains unknown how neutrophils, which are generally short-lived, persist in the skin of patients with Sweet syndrome. We report that Sweet syndrome skin contains a unique population of long-lived antigen-presenting cell (APC)-neutrophils that are not present in blood or unaffected skin.
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