← BioTransfer GEO Dataset Finder
GEO series

Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [human RCC4]

GSE291048 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/25 Platform GPL34284
Summary
Activating transcription factor 4 (ATF4) is a transcription factor that mediates the response to stress at the cellular, tissue, and organism level. We deleted the gene encoding ATF4 in the kidney proximal tubules of the wild type (WT) and TRACK (TRAnsgenic model of Cancer of the Kidney (TRACK)) mice by using a temporal and cell type-specific approach. We show that ATF4 plays a major role in regulating the transcriptome and proteome, which, in turn, influences the metabolome and kidney functions. ATF4 deletion changed transcripts of some transporters responsible for nutrient uptake and waste excretion. It modulates metabolisms of fatty acid and glucose in the mouse model of ccRCC. It also changes metabolism in RCC4 cells. These data indicate that ATF4 plays an important role in regulation of kidney functions.
Published in
Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma
Chi Y, Chikara S, Aguila EMD et al. · Neoplasia (New York, N.Y.) 2025 · PMID 40472739 · doi:10.1016/j.neo.2025.101188
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE291048_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1231461 and SRA study SRP567826. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.