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RNA-Seq profiles of human prostate cancer PC3 cells with TTC3 knockdown.

GSE291122 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/01 Platform GPL30173
Summary
The TTC3 gene is located at 21q22.2, and its protein product functions as an E3 ubiquitin protein ligase, mediating the ubiquitination and subsequent degradation of phosphorylated Akt in the nucleus. TTC3 was reported to play a role in neuronal differentiation inhibition and asymmetric cell division in cancer cells. We found that silencing TTC3 can significantly suppress prostate cancer cell proliferation and growth in vitro and in vivo. To identify targets regulated by TTC3, we performed global gene expression profiling analysis in TTC3-silenced PC3 cells.
Published in
A sensitive and specific non-invasive urine biomarker panel for prostate cancer detection
Yuan M, Moschovas MC, Joshi K et al. · EBioMedicine 2025 · PMID 40903311 · doi:10.1016/j.ebiom.2025.105895
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Also filed as BioProject PRJNA1232031 and SRA study SRP568040. Searching any of these in the dataset finder brings you back here.

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