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Mechanisms of maternal antibody interference to rotavirus vaccination

GSE291166 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/02 Platform GPL34328
Summary
We have employed a single-cell sequencing approach using the 10x Genomics scRNAseq pipeline to study the effect of maternal antibodies on the response to vaccination in the mesenteric lymph node. Given the ability of maternal antibodies to intefere with sero-conversion to rotatvirus vaccination we hypothesized that maternal antibodies would alter the activation and differentiation of lymphocytes. This study presents data on transcriptome dynamics of the mesenteric lymph node following rotavirus vaccination in the absence or presence of maternal antibodies.
Published in
Mechanisms of maternal antibody interference with rotavirus vaccination
Chandler TL, Woodyear S, Chen V et al. · The EMBO journal 2025 · PMID 41087582 · doi:10.1038/s44318-025-00582-2
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Also filed as BioProject PRJNA1232130 and SRA study SRP568105. Searching any of these in the dataset finder brings you back here.

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