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Transcriptome of 3D cultivated colon cancer cell lines (HCT116, SW620, DLD1) and HCEC-1CT

GSE291181 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/09 Platform GPL24676
Summary
The study aimed to identify transcripts of the protein-coding genes that could have regulatory role potentially relevant for malignant transformation of the gut mucosa and colon cancer onset and progression. The set of colon cancer cell lines (HCT116, SW620 and DLD1) and immortalized cells derived from healthy gut mucosa (HCEC-1CT) were cultivated in 3D and their transcriptomes were analyzed by RNA sequencing to profile expression for both coding and non-coding transcripts.
Published in
Comparative RNA-Seq Analysis of Colon Spheroids and Patient-derived Tissues Identifies Non-Canonical Transcript Isoforms of Protein-Coding Genes Implicated in Colon Carcinogenesis
Babic T, Banovic Djeri B, Pavlovic D et al. · Cancer informatics 2025 · PMID 41312429 · doi:10.1177/11769351251396250
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Also filed as BioProject PRJNA1232144 and SRA study SRP568127. Searching any of these in the dataset finder brings you back here.

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