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Autocrine Activity of Engineered IL-33 mRNA Enhances Adoptive T Cell Therapy for Peritoneal Carcinomatosis and Synergizes with IL-12 mRNA

GSE291258 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/06 Platform GPL24247
Summary
Peritoneal carcinomatosis (PC) remains a significant clinical challenge, with limited therapeutic options. Adoptive cell therapy (ACT) using tumor-specific T cells has emerged as a promising strategy; however, its efficacy is often hindered by the immunosuppressive tumor microenvironment (TME). Interleukin-33 (IL-33), a member of the IL-1 family, plays a dual role in immunity and inflammation, with the potential to enhance antitumor responses. Here, we investigated the impact of IL-33 mRNA-engineered T cells on ACT efficacy in murine models of PC and explored the potential synergy with IL-12 mRNA.
Published in
Autocrine activity of engineered IL-33 mRNA enhances adoptive T-cell therapy for peritoneal carcinomatosis and synergizes with IL-12 mRNA
Arrizabalaga L, Di Trani CA, Gomar C et al. · Theranostics 2026 · PMID 41608588 · doi:10.7150/thno.122132
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Also filed as BioProject PRJNA1232672 and SRA study SRP568375. Searching any of these in the dataset finder brings you back here.

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