The placentalia specific histone H3.4 promotes germ cell development and reproductive fitness [RNA-seq]
RNA-seq (gene expression) · mouse · 126 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 126 samples: 36 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitnessNature communications · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291273_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1232700 and SRA study SRP568427. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 126 samples.
How we read this: 36 replicated groups read from 126 sample titles; they account for 126 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8832503 H31_ScLZ_het_rep1 H31_ScLZ_het
- GSM8832504 H31_ScPD_het_rep1 H31_ScPD_het
- GSM8832505 H31_rSt_het_rep1 H31_rSt_het
- GSM8832506 H31_elSt_het_rep1 H31_elSt_het
- GSM8832507 H31_ScLZ_mut_rep1 H31_ScLZ_mut
- GSM8832508 H31_ScPD_mut_rep1 H31_ScPD_mut
- GSM8832509 H31_rSt_mut_rep1 H31_rSt_mut
- GSM8832510 H31_elSt_mut_rep1 H31_elSt_mut
- GSM8832511 H31_ScLZ_wt_rep1 H31_ScLZ_wt
- GSM8832512 H31_ScPD_wt_rep1 H31_ScPD_wt
- GSM8832513 H31_rSt_wt_rep1 H31_rSt_wt
- GSM8832514 H31_elSt_wt_rep1 H31_elSt_wt
- GSM8832515 H31_ScLZ_het_rep2 H31_ScLZ_het
- GSM8832516 H31_ScPD_het_rep2 H31_ScPD_het
- GSM8832517 H31_rSt_het_rep2 H31_rSt_het
- GSM8832518 H31_ScLZ_mut_rep2 H31_ScLZ_mut
- GSM8832519 H31_ScPD_mut_rep2 H31_ScPD_mut
- GSM8832520 H31_rSt_mut_rep2 H31_rSt_mut
- GSM8832521 H31_elSt_mut_rep2 H31_elSt_mut
- GSM8832522 H31_ScLZ_wt_rep2 H31_ScLZ_wt
- GSM8832523 H31_ScPD_wt_rep2 H31_ScPD_wt
- GSM8832524 H31_rSt_wt_rep2 H31_rSt_wt
- GSM8832525 H31_elSt_wt_rep2 H31_elSt_wt
- GSM8832526 H31_ScLZ_het_rep3 H31_ScLZ_het
- GSM8832527 H31_ScPD_het_rep3 H31_ScPD_het
- GSM8832528 H31_rSt_het_rep3 H31_rSt_het
- GSM8832529 H31_elSt_het_rep3 H31_elSt_het
- GSM8832530 H31_ScLZ_mut_rep3 H31_ScLZ_mut
- GSM8832531 H31_ScPD_mut_rep3 H31_ScPD_mut
- GSM8832532 H31_rSt_mut_rep3 H31_rSt_mut
- GSM8832533 H31_elSt_mut_rep3 H31_elSt_mut
- GSM8832534 H31_ScLZ_wt_rep3 H31_ScLZ_wt
- GSM8832535 H31_ScPD_wt_rep3 H31_ScPD_wt
- GSM8832536 H31_rSt_wt_rep3 H31_rSt_wt
- GSM8832537 H31_elSt_wt_rep3 H31_elSt_wt
- GSM8832538 H31_ScLZ_het_rep4 H31_ScLZ_het
- GSM8832539 H31_ScPD_het_rep4 H31_ScPD_het
- GSM8832540 H31_rSt_het_rep4 H31_rSt_het
- GSM8832541 H31_elSt_het_rep4 H31_elSt_het
- GSM8832542 H31_ScLZ_mut_rep4 H31_ScLZ_mut
+ 86 more — browse all 126 samples with per-sample file links →
- GSE291274 The placentalia specific histone H3.4 promotes germ cell development and reproductive fitness 167 samples shares reproductive, placentalia, specific, promotes, histone, fitness, germ
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares specific, rna-seq, germ
- GSE245838 Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity [mouse scRNA-seq] 21 samples shares specific, rna-seq
- GSE288348 Disease-associated astrocyte epigenetic memory promotes CNS pathology [sgEp300, sgACLY astrocytes bulk RNA-Seq dataset] 18 samples shares promotes, rna-seq
- GSE230838 Loss of cisPTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma [RNA-seq] 17 samples shares promotes, rna-seq
- GSE241176 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] 12 samples shares specific, rna-seq
- GSE267910 Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance (snRNA-Seq) 12 samples shares specific, rna-seq
- GSE300299 Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice [scRNA-seq] 12 samples shares promotes, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.