Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation
Single-cell RNA-seq · mouse · 36 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 10 × Myt1l heterozygous male mouse vs 10 × Wildtype female mouse vs 10 × Wildtype male mouse vs 6 × Myt1l heterozygous female mouseGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social MotivationbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291295_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1232789 and SRA study SRP568492. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 4 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8833059 Myt1l heterozygous female mouse 1 Myt1l heterozygous fema…
- GSM8833060 Myt1l heterozygous female mouse 2 Myt1l heterozygous fema…
- GSM8833061 Myt1l heterozygous female mouse 3 Myt1l heterozygous fema…
- GSM8833062 Myt1l heterozygous female mouse 4 Myt1l heterozygous fema…
- GSM8833063 Myt1l heterozygous female mouse 5 Myt1l heterozygous fema…
- GSM8833064 Myt1l heterozygous female mouse 6 Myt1l heterozygous fema…
- GSM8833065 Myt1l heterozygous male mouse 1 Myt1l heterozygous male…
- GSM8833066 Myt1l heterozygous male mouse 10 Myt1l heterozygous male…
- GSM8833067 Myt1l heterozygous male mouse 2 Myt1l heterozygous male…
- GSM8833068 Myt1l heterozygous male mouse 3 Myt1l heterozygous male…
- GSM8833069 Myt1l heterozygous male mouse 4 Myt1l heterozygous male…
- GSM8833070 Myt1l heterozygous male mouse 5 Myt1l heterozygous male…
- GSM8833071 Myt1l heterozygous male mouse 6 Myt1l heterozygous male…
- GSM8833072 Myt1l heterozygous male mouse 7 Myt1l heterozygous male…
- GSM8833073 Myt1l heterozygous male mouse 8 Myt1l heterozygous male…
- GSM8833074 Myt1l heterozygous male mouse 9 Myt1l heterozygous male…
- GSM8833075 Wildtype female mouse 1 Wildtype female mouse
- GSM8833076 Wildtype female mouse 10 Wildtype female mouse
- GSM8833077 Wildtype female mouse 2 Wildtype female mouse
- GSM8833078 Wildtype female mouse 3 Wildtype female mouse
- GSM8833079 Wildtype female mouse 4 Wildtype female mouse
- GSM8833080 Wildtype female mouse 5 Wildtype female mouse
- GSM8833081 Wildtype female mouse 6 Wildtype female mouse
- GSM8833082 Wildtype female mouse 7 Wildtype female mouse
- GSM8833083 Wildtype female mouse 8 Wildtype female mouse
- GSM8833084 Wildtype female mouse 9 Wildtype female mouse
- GSM8833085 Wildtype male mouse 1 Wildtype male mouse
- GSM8833086 Wildtype male mouse 10 Wildtype male mouse
- GSM8833087 Wildtype male mouse 2 Wildtype male mouse
- GSM8833088 Wildtype male mouse 3 Wildtype male mouse
- GSM8833089 Wildtype male mouse 4 Wildtype male mouse
- GSM8833090 Wildtype male mouse 5 Wildtype male mouse
- GSM8833091 Wildtype male mouse 6 Wildtype male mouse
- GSM8833092 Wildtype male mouse 7 Wildtype male mouse
- GSM8833093 Wildtype male mouse 8 Wildtype male mouse
- GSM8833094 Wildtype male mouse 9 Wildtype male mouse
- GSE277789 Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution [Smart-seq3-RNA-seq-add] 830 samples shares single-cell, resolution
- GSE150817 Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution 30 samples shares single-cell, resolution
- GSE310028 Dissecting Semaglutide-dependent transcriptome response in obesity and osteoarthritis across tissues at single-cell resolution 28 samples shares single-cell, resolution
- GSE266497 Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution [10x-v3-RNA-seq] 13 samples shares single-cell, resolution
- GSE294795 Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution 12 samples shares single-cell, resolution
- GSE192687 Single-cell RNAseq analysis of renal endothelial cells in murine diabetic nephropathy 5464 samples shares single-cell
- GSE290574 Gene Regulatory Networks Orchestrating Oocyte Fate Bifurcation in Primordial Follicles Revealed by Single-Cell Transcriptomics 386 samples shares single-cell
- GSE166225 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq] 288 samples shares single-cell
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.