GEO series
Epigenomic profiling of circulating chromatin to detect and monitor squamous transformation in prostate cancer
GSE291318
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing; Other
12 samples
2025/07/06
GPL24676
Summary
Transformation to squamous cell carcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype.
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Paper (PMID 40634667) ↗
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