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Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma

GSE291357 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/04 Platform GPL28330
Summary
STS was found to attenuate tumor progression by inducing tumor-associated macrophages (TAMs) to switch to an antitumoral phenotype, enhancing phagocytosis of tumor cells, and stimulating subsequent antitumor immunity of CD8+ T cells as demonstrated in 3 HCC mouse models, NCG mice, and Rag2-KO mice. Furthermore, STS combined with anti-PD1/L1 suppressed tumor progression, while the efficacy of anti-programmed cell death 1 ligand 1 (PD-L1) was improved when combined with STS. Our data therefore provide information on gene expression changes in liver tumor tissue in mice after starvation.
Published in
Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma
Cheng K, Cai N, Yang X et al. · Hepatology (Baltimore, Md.) 2025 · PMID 39879585 · doi:10.1097/HEP.0000000000001244
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Also filed as BioProject PRJNA1233230. Searching any of these in the dataset finder brings you back here.

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