A conserved function of EZH2-PRC2 in the repression of primitive endoderm cell fate [CUT&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A conserved function of EZH2-PRC2 in repression of primitive endoderm fate in mouse and human pluripotent cellsStem cell reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291366_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1233250 and SRA study SRP568682. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8833933 ESCH3K27me3 rep1 ESCH3K27me3
- GSM8833934 ESCH3K27me3 rep2 ESCH3K27me3
- GSM8833935 PrESC-H3K27me3 rep1 PrESC-H3K27me3
- GSM8833936 PrESC-H3K27me3 rep2 PrESC-H3K27me3
- GSM8833937 EZH2KO-10-H3K27me3 rep1 EZH2KO-10-H3K27me3
- GSM8833938 EZH2KO-10-H3K27me3 rep2 EZH2KO-10-H3K27me3
- GSM8833939 EZH2KO-12-H3K27me3 rep1 EZH2KO-12-H3K27me3
- GSM8833940 EZH2KO-12-H3K27me3 rep2 EZH2KO-12-H3K27me3
- GSM8833941 EZH2-10-rescued-H3K27me3 rep1 EZH2-10-rescued-H3K27me3
- GSM8833942 EZH2-10-rescued-H3K27me3 rep2 EZH2-10-rescued-H3K27me3
- GSM8833943 EZH2-12-rescued-H3K27me3 rep1 EZH2-12-rescued-H3K27me3
- GSM8833944 EZH2-12-rescued-H3K27me3 rep2 EZH2-12-rescued-H3K27me3
- GSE303384 Mechanism of maintenance and establishment of repression by the Mtg16 tumor suppressor [CUT&RUN, ChIP-Seq] 92 samples shares cut, repression
- GSE294521 Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [CUTnTAG] 34 samples shares cut, endoderm
- GSE316942 Bcl11a orchestrates multilineage integrity in aging hematopoiesis by regulating multipotent progenitor fate decisions [CUT&Tag] 16 samples shares cut, fate
- GSE304391 Global identification of ER stress-regulated RNA binding Proteins in clonal pancreatic beta-cells, reveals an important role for DEAD-box helicase 3 X-linked (DDX3X) in the execution of the Unfolded Protein Response and the determination of cell fate. 12 samples shares cut, fate
- GSE264602 Recruitment to the nuclear periphery enhances repression of H3K9me2-marked genes and transposons to shape cell fate [RNAseq_shLBR] 43 samples shares repression, fate
- GSE274875 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [Cut & Run] 38 samples shares cut
- GSE225202 REV-ERBα regulates regulatory T cell function in inflammatory bowel disease [CUT&RUN] 29 samples shares cut
- GSE304211 H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions [CUTnTAG] 128 samples shares cut
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.