T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis [RNA-seq]
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasisThe Journal of clinical investigation · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291446_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1233779 and SRA study SRP568964. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 8 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8835774 WT_Lung_Naive_1 WT_Lung_Naive
- GSM8835775 WT_Lung_Naive_2 WT_Lung_Naive
- GSM8835776 WT_Lung_Naive_3 WT_Lung_Naive
- GSM8835777 WT_Lung_Flu_1 WT_Lung_Flu
- GSM8835778 WT_Lung_Flu_2 WT_Lung_Flu
- GSM8835779 WT_Lung_Flu_3 WT_Lung_Flu
- GSM8835780 Kdm6b_Lung_Naive_1 Kdm6b_Lung_Naive
- GSM8835781 Kdm6b_Lung_Naive_2 Kdm6b_Lung_Naive
- GSM8835782 Kdm6b_Lung_Naive_3 Kdm6b_Lung_Naive
- GSM8835783 Kdm6b_Lung_Flu_1 Kdm6b_Lung_Flu
- GSM8835784 Kdm6b_Lung_Flu_2 Kdm6b_Lung_Flu
- GSM8835785 Kdm6b_Lung_Flu_3 Kdm6b_Lung_Flu
- GSM8835786 noTCR_WT_1 noTCR_WT
- GSM8835787 noTCR_WT_2 noTCR_WT
- GSM8835788 TCR_3h_WT_1 TCR_3h_WT
- GSM8835789 TCR_3h_WT_2 TCR_3h_WT
- GSM8835790 noTCR_Kdm6b_1 noTCR_Kdm6b
- GSM8835791 noTCR_Kdm6b_2 noTCR_Kdm6b
- GSM8835792 TCR_3h_Kdm6b_1 TCR_3h_Kdm6b
- GSM8835793 TCR_3h_Kdm6b_2 TCR_3h_Kdm6b
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples shares kdm6b, demethylase, homeostasis, receptor, maintain, induces, lysine
- GSE286398 Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation [scRNA-seq] 13 samples shares demethylase, rna-seq, lysine
- GSE305767 Kdm6b-mediated epigenetic coordination of temporal precision during motor neuron differentiation [RNA-seq] 21 samples shares kdm6b, rna-seq
- GSE306262 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [RNA-seq] 40 samples shares receptor, rna-seq
- GSE240578 MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis 20 samples shares homeostasis, receptor
- GSE309618 Mesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture 18 samples shares homeostasis, maintain
- GSE276730 The histone lysine demethylase KDM7A contributes to reward memory via Fscn1-induced synaptic plasticity in the medial prefrontal cortex 16 samples shares demethylase, lysine
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares homeostasis, receptor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.