T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis [CUT&Run]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasisThe Journal of clinical investigation · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291448_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1233778 and SRA study SRP568966. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 5 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8835854 H3K27me3-Kdm6b_Lung_Flu_1 H3K27me3-Kdm6b_Lung_Flu
- GSM8835855 H3K27me3-Kdm6b_Lung_Flu_2 H3K27me3-Kdm6b_Lung_Flu
- GSM8835856 H3K27me3-Kdm6b_Lung_Flu_3 H3K27me3-Kdm6b_Lung_Flu
- GSM8835857 H3K27me3-Kdm6b_Lung_PBS_1 H3K27me3-Kdm6b_Lung_PBS
- GSM8835858 H3K27me3-Kdm6b_Lung_PBS_2 H3K27me3-Kdm6b_Lung_PBS
- GSM8835859 H3K27me3-Kdm6b_Lung_PBS_3 H3K27me3-Kdm6b_Lung_PBS
- GSM8835860 H3K27me3-WT_Lung_Flu_1 H3K27me3-WT_Lung_Flu
- GSM8835861 H3K27me3-WT_Lung_Flu_2 H3K27me3-WT_Lung_Flu
- GSM8835862 H3K27me3-WT_Lung_Flu_3 H3K27me3-WT_Lung_Flu
- GSM8835863 H3K27me3-WT_Lung_PBS_1 H3K27me3-WT_Lung_PBS
- GSM8835864 H3K27me3-WT_Lung_PBS_2 H3K27me3-WT_Lung_PBS
- GSM8835865 H3K27me3-WT_Lung_PBS_3 H3K27me3-WT_Lung_PBS
- GSM8835866 Kdm6b_CR_Treg_1 Kdm6b_CR_Treg
- GSM8835867 Kdm6b_CR_Treg_2 Kdm6b_CR_Treg
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples shares kdm6b, demethylase, homeostasis, receptor, maintain, induces, lysine
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples shares cut, receptor
- GSE319420 Uncovering Critical Lysines in Mammalian Histone H3 with High-Throughput CRISPR Prime Editing [CUT&Tag] 26 samples shares cut, lysine
- GSE326538 Aqueous Artemisia argyi extract mitigates acute lung injury by coordinating gut microbiota, metabolic homeostasis, and pulmonary inflammatory signaling 24 samples shares cut, homeostasis
- GSE240787 DNMT3b mediates TGFβ-Smad2/3 action to maintain Epiblast homeostasis upon Smad4 Loss 34 samples shares homeostasis, maintain
- GSE240578 MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis 20 samples shares homeostasis, receptor
- GSE309618 Mesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture 18 samples shares homeostasis, maintain
- GSE276730 The histone lysine demethylase KDM7A contributes to reward memory via Fscn1-induced synaptic plasticity in the medial prefrontal cortex 16 samples shares demethylase, lysine
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.