MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × Liver, WT, vs 5 × Liver, IR 4A, vs 5 × eWAT, WT, vs 5 × eWAT, IR 4A,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic HomeostasisDiabetes · 2023
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240578_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1004260 and SRA study SRP454532. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7702846 Liver, WT, replicate 1 Liver, WT,
- GSM7702847 Liver, WT, replicate 2 Liver, WT,
- GSM7702848 Liver, WT, replicate 3 Liver, WT,
- GSM7702849 Liver, WT, replicate 4 Liver, WT,
- GSM7702850 Liver, WT, replicate 5 Liver, WT,
- GSM7702851 Liver, IR 4A, replicate 1 Liver, IR 4A,
- GSM7702852 Liver, IR 4A, replicate 2 Liver, IR 4A,
- GSM7702853 Liver, IR 4A, replicate 3 Liver, IR 4A,
- GSM7702854 Liver, IR 4A, replicate 4 Liver, IR 4A,
- GSM7702855 Liver, IR 4A, replicate 5 Liver, IR 4A,
- GSM7702856 eWAT, WT, replicate 1 eWAT, WT,
- GSM7702857 eWAT, WT, replicate 2 eWAT, WT,
- GSM7702858 eWAT, WT, replicate 3 eWAT, WT,
- GSM7702859 eWAT, WT, replicate 4 eWAT, WT,
- GSM7702860 eWAT, WT, replicate 5 eWAT, WT,
- GSM7702861 eWAT, IR 4A, replicate 1 eWAT, IR 4A,
- GSM7702862 eWAT, IR 4A, replicate 2 eWAT, IR 4A,
- GSM7702863 eWAT, IR 4A, replicate 3 eWAT, IR 4A,
- GSM7702864 eWAT, IR 4A, replicate 4 eWAT, IR 4A,
- GSM7702865 eWAT, IR 4A, replicate 5 eWAT, IR 4A,
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares homeostasis, receptor
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples shares homeostasis, receptor
- GSE326538 Aqueous Artemisia argyi extract mitigates acute lung injury by coordinating gut microbiota, metabolic homeostasis, and pulmonary inflammatory signaling 24 samples shares homeostasis
- GSE309415 Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing 12 samples shares receptor
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares homeostasis
- GSE293590 Transcriptome-guided GLP-1 receptor therapy rescues metabolic and behavioral disruptions in a Bardet-Biedl Syndrome mouse model 10 samples shares receptor
- GSE325494 Pharmacological inhibition of GLUT1 alleviates fulminant hepatitis by restraining macrophage-induced inflammatory cascades and restoring metabolic homeostasis 9 samples shares homeostasis
- GSE263602 The p75 neurotrophin receptor regulates the skeletal stem cell niche through sensory innervation 14 samples shares receptor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.