PLCG2 modulates TREM2 expression and signaling in response to Alzheimer’s disease pathology
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathologyAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291648_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1234569 and SRA study SRP569650. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 18 samples read as cases, 6 as controls.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8839326 M1-1177, WT, 5xFAD, 7.5Month, Cortex, male
- GSM8839327 M2-1181, WT, 5xFAD, 7.5Month, Cortex, male
- GSM8839328 M3-1182, WT, 5xFAD, 7.5Month, Cortex, male
- GSM8839329 F1-1180, WT, 5xFAD, 7.5Month, Cortex, female
- GSM8839330 F2-1189, WT, 5xFAD, 7.5Month, Cortex, female
- GSM8839331 F3-1190, WT, 5xFAD, 7.5Month, Cortex, female
- GSM8839332 M1-40, Trem2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839333 M2-41, Trem2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839334 M3-45, Trem2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839335 F1-42, Trem2 Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839336 F2-44, Trem2 Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839337 F3-46, Trem2 Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839338 M1-62, PLCG2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839339 M2-110, PLCG2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839340 M3-130, PLCG2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839341 M4-134, PLCG2 Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839342 F1-83, PLCG2 Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839343 F2-137, PLCG2 Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839344 M1-11, PLCG2 Heterozygous Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839345 M2-13, PLCG2 Heterozygous Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839346 M3-3, PLCG2 Heterozygous Knockout, 5xFAD, 7.5Month, Cortex, male
- GSM8839347 F1-8, PLCG2 Heterozygous Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839348 F2-12, PLCG2 Heterozygous Knockout, 5xFAD, 7.5Month, Cortex, female
- GSM8839349 F3-14, PLCG2 Heterozygous Knockout, 5xFAD, 7.5Month, Cortex, female
- GSE316055 Differential downstream signaling in microglia lacking Alzheimer’s-related TREM2 or its adaptor TYROBP/DAP12 72 samples shares trem2, alzheimer
- GSE176506 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease 112 samples shares alzheimer, pathology
- GSE304521 SEX-DEPENDENT TYPE I INTERFERON SIGNALING EXACERBATES ALZHEIMER'S PATHOLOGY 82 samples shares alzheimer, pathology
- GSE277167 Protective variant in PLCγ2 mitigates Alzheimer’s disease associated pathology via enhancing beneficial microglia functions 31 samples shares alzheimer, pathology
- GSE288170 Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice 20 samples shares alzheimer, pathology
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares trem2
- GSE318801 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. 20 samples shares trem2
- GSE318804 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. [macro_senescence] 12 samples shares trem2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.