GEO series
SEX-DEPENDENT TYPE I INTERFERON SIGNALING EXACERBATES ALZHEIMER'S PATHOLOGY
GSE304521
Mus musculus
Expression profiling by high throughput sequencing
82 samples
2026/05/12
GPL24247
Summary
Alzheimer’s disease (AD) disproportionately affects women, but the biological basis for this sex difference remains unclear. Using transcriptomic profiling of postmortem human AD brain tissue, we identified a sex-specific enrichment of interferon-alpha (IFN-α) signaling pathways in females. This immune signature was recapitulated in APP/PS1 transgenic mouse models, where female mice exhibited greater amyloid pathology, neuroinflammation, and neurodegeneration compared to males.
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Paper (PMID 42083037) ↗
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