Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key players
Single-cell RNA-seq · human · 23 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Cervical cancerThis series is part of our curated briefing on it.
- Samples
- 23 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key playersFrontiers in immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291865_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1235690 and SRA study SRP570261. Searching any of these in the dataset finder brings you back here.
The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Sample titles run patient1 … patient23 and carry no group information.
- GSM8843588 patient1
- GSM8843589 patient2
- GSM8843590 patient3
- GSM8843591 patient4
- GSM8843592 patient5
- GSM8843593 patient6
- GSM8843594 patient7
- GSM8843595 patient8
- GSM8843596 patient9
- GSM8843597 patient10
- GSM8843598 patient11
- GSM8843599 patient12
- GSM8843600 patient13
- GSM8843601 patient14
- GSM8843602 patient15
- GSM8843603 patient16
- GSM8843604 patient17
- GSM8843605 patient18
- GSM8843606 patient19
- GSM8843607 patient20
- GSM8843608 patient21
- GSM8843609 patient22
- GSM8843610 patient23
- GSE316098 Spatial Transcriptomic Landscape of Invasion Patterns in Human Papillomavirus-Associated Endocervical Adenocarcinoma 186 samples same disease briefing · shares cervical
- GSE303300 Neoadjuvant Immune Checkpoint Blockade Before Chemoradiation for Patients with FIGO Stage IB3–IVA Cervical Squamous Carcinoma: GINECO Window-Of-Opportunity COLIBRI Study 96 samples same disease briefing · shares cervical
- GSE168244 Patient-derived organoids as a platform to study cervical cancer and viral infection 36 samples same disease briefing · shares cervical
- GSE299125 Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways 35 samples same disease briefing · shares cervical
- GSE297038 Chemoradiation Reprograms Tumor Cells and Immune Microenvironment In Cervical Cancer [bulk RNA-seq] 34 samples same disease briefing · shares cervical
- GSE275914 RNA sequencing of 31 pre-treatment, primary cervical cancer samples 31 samples same disease briefing · shares cervical
- GSE264492 Transcriptomic analysis reveals Streptococcus agalactiae activation of oncogenic pathways in cervical adenocarcinoma 24 samples same disease briefing · shares cervical
- GSE311189 Integrated Transcriptomic and Functional Analysis Reveals Selective Cytotoxicity and Oncogene Suppression Induced by Cinnamon Essential Oil in Cervical Cancer Cells 24 samples same disease briefing · shares cervical
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.