GEO series
Bacterial pneumonia induces senescence in resident alveolar macrophages that are outcompeted by monocytes
GSE292009
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2025/04/11
GPL34290
Summary
This study show that embryonic-derived resident alveolar macrophages recovered from acute respiratory Streptococcal pneumoniae infection show features of cell senescence and reduced proliferation capacity. In the weeks after resolution of infection, these senescent resident alveolar macrophages are outcompeted by monocyte-derived alveolar macrophages with hyper-immunoreactivity and heterologous anti-infectious functions.
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Paper (PMID 40249704) ↗
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