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Transcriptome analyses of fetal testicular interstitial cells (W-EGFP) treated with Smoothened Agonist (SAG)

GSE292010 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/24 Platform GPL24247
Summary
Fetal Leydig cells are essential for masculinization through androgen production during fetal development. Previous studies have indicated that Desert Hedgehog regulates differentiation from progenitor cells. Our previous research showed a significant upregulation of energy metabolism-related genes during fetal Leydig cell differentiation. However, the underlying regulatory mechanisms remain unresolved. Here, we reveal that Desert Hedgehog rapidly activates energy metabolisms in testicular interstitial cells (W-EGFP cells) containing fetal Leydig progenitor cells without activating gene expression.
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Direct links to NCBI, no account and no request form: the whole study as GSE292010_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1236323 and SRA study SRP570495. Searching any of these in the dataset finder brings you back here.

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