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Genetic deletion of RUNX1 or RUNX2 in adipocytes enhanced beige fat formation [ChIP-Seq; CUT&Tag]

GSE292265 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 56 samples Submitted 2026/02/12 Platform GPL34290
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 56 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
56 samples: 26 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanismsNature communications · 2026
Summary (written by the submitters)
RUNX1 and RUNX2 repress thermogenic gene expression by directly binding to their regulatory genomic regions, thereby acting as key transcriptional repressors of adipocyte thermogenesis. Furthermore, RUNX1 preferentially interacts with HDAC1 to modulate thermogenic gene expression.
Published in
Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms
Wang C, He N, Wang S et al. · Nature communications 2026 · PMID 41927567 · doi:10.1038/s41467-026-71266-6
This dataset
Open GSE292265 in finder → Find more mouse ChIP / ATAC / CUT&Tag datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292265_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1237778 and SRA study SRP571326. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41927567) ↗
Study design
26 conditions, mostly in duplicate
BAT, H3K27ac CUT&Tag, ×2 BAT, OE Runx1, H3K27ac CUT&Tag, ×2 BAT, OE Runx2, H3K27ac CUT&Tag, ×2 BAT, HDAC1 CUT&Tag, ×2 BAT, OE Runx1, HDAC1 CUT&Tag, ×2 BAT, OE Runx2, HDAC1 CUT&Tag, ×2 BAT, HDAC2 CUT&Tag, ×2 BAT, OE Runx1, HDAC2 CUT&Tag, ×2 +22 more

Supports a between-group comparison across 52 samples.

How we read this: 26 replicated groups read from 56 sample titles; they account for 52 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 16 more — browse all 56 samples with per-sample file links →

Datasets on a similar topic

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.