GEO series
Genetic deletion of RUNX1 or RUNX2 in adipocytes enhanced beige fat formation [ChIP-Seq; CUT&Tag]
GSE292265
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
56 samples
2026/02/12
GPL34290
Summary
RUNX1 and RUNX2 repress thermogenic gene expression by directly binding to their regulatory genomic regions, thereby acting as key transcriptional repressors of adipocyte thermogenesis. Furthermore, RUNX1 preferentially interacts with HDAC1 to modulate thermogenic gene expression.
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NCBI GEO page ↗
Paper (PMID 41927567) ↗
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