Targeting ATF6 Reduces Pathological Neovascularization and Improves Visual Outcomes in Retinal Disease Models
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × WT vs 5 × Atf6KO vs 5 × PBS vs 5 × CeapinA7Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease modelsScientific reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292097_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1236858 and SRA study SRP570783. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8848851 WT_1 WT
- GSM8848852 WT_2 WT
- GSM8848853 WT_3 WT
- GSM8848854 WT_4 WT
- GSM8848855 WT_5 WT
- GSM8848856 Atf6KO_1 Atf6KO
- GSM8848857 Atf6KO_2 Atf6KO
- GSM8848858 Atf6KO_3 Atf6KO
- GSM8848859 Atf6KO_4 Atf6KO
- GSM8848860 Atf6KO_5 Atf6KO
- GSM8848861 PBS_1 PBS
- GSM8848862 PBS_2 PBS
- GSM8848863 PBS_3 PBS
- GSM8848864 PBS_4 PBS
- GSM8848865 PBS_5 PBS
- GSM8848866 CeapinA7-1 CeapinA7
- GSM8848867 CeapinA7-2 CeapinA7
- GSM8848868 CeapinA7-3 CeapinA7
- GSM8848869 CeapinA7-4 CeapinA7
- GSM8848870 CeapinA7-5 CeapinA7
- GSE296071 Selective targeting of mutant huntingtin intron-1 improves rescue provided by antisense oligonucleotides in HTT.Q111/+ mice 30 samples shares targeting, improves
- GSE248272 Therapeutically targeting perivascular macrophage effector function improves CD8+ T-cell infiltration and response to chemotherapeutic drugs in cancer 30 samples shares targeting, improves
- GSE325169 Correcting the immune microenvironment disturbed by the overactivation of the neutrophil-driven microglia positive feedback loop efficiently suppressed pathological retinal angiogenesis 12 samples shares pathological, retinal
- GSE300401 Targeting cancer-associated fibroblast-mediated LIF/LIFR axis improves the therapeutic efficacy of gemcitabine and nab-paclitaxel in pancreatic cancer 12 samples shares targeting, improves
- GSE247122 Effect of acute and chronic ATF6 activation on gene expression in the colonic epithelium, in specific pathogen-free and germ-free mice. 37 samples shares atf6
- GSE244342 Activated-ATF6α is an ER stress-inducing oncoprotein metabolically restricting immunosurveillance [bulk RNA-seq of TG-AAV-GFP/CRE, DEN/HFD] 16 samples shares atf6
- GSE244212 Liver transcriptomic profile of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice 12 samples shares atf6
- GSE284500 Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a 192 samples shares targeting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.